8 facts and 15 FAQs on Esmopraz 40mg by Amtech

Esmopraz is an oral only esomeprazole by Amtech Med Private Limited.  It is a proton pump inhibitor and contains esomeprazole magnesium trihydrate tablets 40mg. This product has its basis from Indian pharmacopeia.

Amtech Med is a WHO-GMP pharma company with its headquarters in Morang, Nepal.

esmopraz; esmopraz 40mg amtech

Esmopraz 40mg works by inhibiting the enzyme H+/K+ ATPase in your stomach. By inhibiting this enzyme, acid secretion in your gut decreases. Further, acid production ceases and improves your symptoms.

1. Indications of Esmopraz

Your physician may prescribe Esmopraz on several occasions. The most common one is a pain abdomen due to peptic ulcers. You may have to take for a month or two for this condition. Your doctor may prescribe once or twice daily depending on the severity.

Besides that, it may be a part of a triple regimen for treating Helicobacter pylori infection as well. It is also a choice in stress ulcers, bleeding ulcers, GERD and Zollinger Ellison syndrome. Doctors also use this drug for prophylaxis of aspiration pneumonia.

What are other alternatives to this drug?

  1. Esozol by Quest
  2. Esnow
  3. Esoflux
  4. Sompraz
  5. Nexpro Fast
  6. Esotop by Asian

2. How does Esmopraz work in your illness? 

1. In Peptic Ulcers 

This drug works best for peptic ulcers when you take it once or twice daily. You should take this drug at least one hour before the meal for the best results. The basis by which this great medicine works is by reducing the amount of gastric acid produced in your stomach. After you start Esmopraz, there is a decrease in the further growth of your ulcer. You may have to use other drugs alongside as well depending upon the severity. 

2. In Stress ulcers 

Taking this wonderful medicine in stress ulcers reduces the amount of gastric acid. This will improve your condition. Stress ulcers occur in various traumatic and non-traumatic conditions in your body. So, other medicines, proper rest and stress relief are equally important to allow your body heal.

3. In Heartburn

The mechanism by which this brand of esomeprazole works in this condition is similar to above conditions. By reducing the amount of hydrochloric acid, there is decrease in the mucosal irritation. This relieves pain and soothes your upper gastrointerstinal tract.

4. In Gastroesophageal Reflux disease (GERD)

In GERD, there will be chronic reflux of gastric acid towards your esophagus. By reducing the amount of this acid, there will be a decrease in your symptoms like pain. It also prevents re-injury. However, this may take some weeks to manifest. Besides, taking Esmopraz, you must also make lifestyle changes. This includes taking ample amounts of water and getting weight loss. Similarly, avoiding food at least 4-5 hours of bed will be synergistic to the drug’s effect. 

3.Safety Concerns about Esmopraz 40mg

Do not take this medicine with alcohol. Esomeprazole is safe in pregnancy because it falls in FDA pregnancy category B. Considering lactation, it is usually safe. But, we recommend, you contact your doctor before use. You can use this drug while driving. This drug is safe in kidney and liver diseases.

4. Superiority over other groups of PPI  

Esomeprazole, rabeprazole and pantoprazole are superior to omeprazole . Though the mechanism of action is similar, this Amtech medicine has less affinity for cytochrome P450 (CYP2C19). Hence drug interactions are less. Further it is more acid stable and has more oral bioavailability than omeprazole.

5. HOW TO USE these esmoperazole TABLETS?

You must take this PPI in an empty stomach at least one hour before the meal. Do not chew, crush or break this enteric coated tablet. If in case, you have to take twice, you must take it one hour before major meal in the evening. Please don’t take any solid or liquid items during this one hour interval.

Esmopraz, Esmopraz 40mg Amtech

6. Quick tips about Rapzol

  • Take Esmopraz in the morning. Avoid any food (solid or liquid), for at least one hour after intake. 
  • You can well tolerate this drug. But, you must take in time and avoid certain things. 
  • Avoid beverages, alcohol and smoking while taking this medicine for best results.  
  • Consult your doctor if you don’t see any effect for 2 weeks after using Esmopraz. 
  • Don’t stop taking this medicine before consulting your doctor. 
  • Call your doctor immediately if you develop edema, decreased urination, severe vomiting and rashes

7. 14 FAQs about Esmopraz 40mg

1. What is the use of Esmopraz?

It is a brand name of a esomeprazole, which belongs to the class of proton pump inhibitors. It works by decreasing the production of gastric acid. It’s use are chiefly in peptic ulcer, GERD and heartburn. 

2. What is the best time to take these PPI? 

The best time is in the early morning, as soon as you get off the bed. If you have to take twice, take this drug at least one hour before your meal both in the morning and evening. Don’t take any fluids or solid meals during this period. 

3. How long does it take for Esmopraz to work? 

Action of this medicine starts within one hour. But to get ample relief you will have to take this drug for at least 2-4 weeks. You may still have some symptoms during this time. 


Contact your health personnel immediately in this regard. Though there are no such systemic toxicity and antidotes for this drug, we request you be vigilant. 

5. Does this drug cause weight gain? 

There are only a few reports that this and other brands of this ppi may cause weight gain while intaking this drug. So, consult your doctor for any weight gain concerns 

6. Can I take this drug if I am fasting? 

Yes, you can take Esmopraz, if you are fasting or even intermittent fasting. 

7. What other dietary changes should I make while taking Esmopraz? 

We recommend you take a lot of fibers, decrease excess oil and fat consumption. Refrain from caffeine and carbonated beverages.

8. Can I take antacids with this medicine? 

You can take antacids with this drug. But please take them at least two hours prior or after. In severe spasmodic gastritis, you can take half bottle of antacids like Digene and Tricaine MPS.


Yes, this brand of rabeprazole is safe in most of the conditions. We recommend talking to your doctor to get best results in this scenario. 

10. Can I stop taking Esmopraz if I feel better? 

We don’t recommend this. If you stop taking this medicine abruptly, there may be a surge of acid production. This will worsen your condition. Consult your physician before stopping this drug

11. Can I take painkillers with this drug ? 

Rapzol and other brands are frequently prescribed together with painkillers. NSAIDS are known to cause stress ulcers. Hence, we recommend taking this drug along with painkillers. The dose and duration remains the same as above. 

12. Can I take this drug with alcohol? 

Alcohol doesn’t interfere in the mechanism of action of Esmopraz 40mg. But it may increase acid production as a side effect. To prevent further worsening of your stomach, don’t take alcohol with this drug. 

13. What are the potential side effects of this drug?

The potential side effects are nausea and vomiting. Additionally, there may be rashes, insomnia and abdominal pain. If you consume for more than one year, you may suffer from hypomagnesemia, peripheral neuritis and osteoporosis.

14. Is Esmopraz injection available?

At this moment, it is not available. However, the company may have plans to launch the injection in near future.

15. Is Esmopraz available in 20mg?

Currently, 20mg formulation of this drug is not available. Amtech may have plans to do so.

8. Summary: Esmopraz 40mg

  • Chemical Class: MethylSulfinylbenzimidazole
  • Manufacturer: Amtech Med
  • Available in combination: –
  • Addiction: None   
  • Bioavailability: 70-80%
  • Metabolism: Liver 
  • Excretion: Faeces, Urine 
  • Therapeutic class: Gastrointestinal 
  • Action class: PPI 
  • Price: Ten Rupees for each tablet
  • License Number: 12340
  • Drug Type: Category B 
  • Availability: In all pharmacies, Online pharmacies in Nepal
  • Prescription Required? : Yes for tablet

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