What is the gene involved in clear cell chondrosarcoma?


What is the gene involved in clear cell chondrosarcoma?

a. USP6

b. PAX3

c. ASPL

d. ATF1

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Correct answer id D . ATF1 is involved in clear cell chondrosarcoma. EWS is also involved in various forms of chondrosarcoma, which is not the option in the above question

USP6 is involved in aneursymal bone cyst. This gene is present in short arm of chromosome 17 (17p13). The mechanism is translocation: t(16;17)(q22:p13)

ASPL is involved in alveolar soft tissue sarcoma

PAX3 is involved in alveolar rhabdomyosarcoma

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Let’s detail into this tumour

  • It is a low grade tumour characterized by clear cytoplasm of tumour cells.
  • Affects males more than females (M:F = 2.6:1)

clear cell chondrosarcoma Pathology

 


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