Is apo-CIII an LPL inhibitor? Find out more

Lipoprotein lipase inhibitor or LPL inhibitor is one of the important topics to know if you are a med student. By now most of you might have heard that APO-CII is an LPL activator. But what about LPL inhibitor?

Question:

Which of the following is an LPL inhibitor?

a. ApoA-I
b. ApoC-II
c. ApoC-III
d. ApoE

Correct answer : c. Apo C-III

Explanation

Wikipedia has a good description of the interaction of lipoprotein lipases (LPL)  . While LPL is activated by ApoC-II, it is inhibited by ApoCIII.   Lipoprotein lipase (LPL)  belongs to the  lipase gene family, which contains pancreatic lipase, hepatic lipase and endothelial lipase as few types.

Lipoprotein Lipase Function of lipoprotein lipase; LPL inhibitor, LPL apo c3

Apolipoprotein C-III also known as apo-CIII  is made by the APOC3 gene in humas. It inhibits both lipoprotein lipase as well as hepatic lipase.

Final words

ApoC-III is produced in liver, intestine, inhibits LPL activity and lipoprotein binding to receptors. Reduction in LPL activity often contributes to the dyslipidemia.

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