Is apo-CIII an LPL inhibitor? Find out more

Lipoprotein lipase inhibitor or LPL inhibitor is one of the important topics to know if you are a med student. By now most of you might have heard that APO-CII is an LPL activator. But what about LPL inhibitor?


Which of the following is an LPL inhibitor?

a. ApoA-I
b. ApoC-II
c. ApoC-III
d. ApoE

Correct answer : c. Apo C-III


Wikipedia has a good description of the interaction of lipoprotein lipases (LPL)  . While LPL is activated by ApoC-II, it is inhibited by ApoCIII.   Lipoprotein lipase (LPL)  belongs to the  lipase gene family, which contains pancreatic lipase, hepatic lipase and endothelial lipase as few types.

Lipoprotein Lipase Function of lipoprotein lipase; LPL inhibitor, LPL apo c3

Apolipoprotein C-III also known as apo-CIII  is made by the APOC3 gene in humas. It inhibits both lipoprotein lipase as well as hepatic lipase.

Final words

ApoC-III is produced in liver, intestine, inhibits LPL activity and lipoprotein binding to receptors. Reduction in LPL activity often contributes to the dyslipidemia.

7 responses to “Is apo-CIII an LPL inhibitor? Find out more”

  1. whoa! this blog is magnificent i love reading your articles. Keep up the good work! You know, many people are looking around for this info, you can aid them greatly.

  2. Currently it appears like Drupal is the preferred blogging platform out there right now. (from what I’ve read) Is that what you are using on your blog?

  3. Throughout this awesome pattern of things you actually secure a A + just for effort and hard work. I do not make it a regular habit of doing that. I am convinced of how you seem to connect your details that help to make the actual conclusion. For now I shall yield to your point but
    and trust in the foreseeable future you link your dots much better.

  4. This is relevant knowledge for my followers, so I’ll link back to this post and you will likely get some new readers.

Leave a Reply

Your email address will not be published. Required fields are marked *