P-Gut 40mg tablets – Everything you must know

P-Gut 40mg tablet is an oral pantoprazole by Madras Pharmaceuticals. It also has its injection form in the same name.


P-Gut 40mg is a proton pump inhibitor. It acts by inhibiting H+/K+ ATPase in the stomach. It is one of the most popular drugs in Nepal. Additionally, Madras Pharmaceuticals is a favorite brand amongst both doctors and patients.

P-GUT 40mg

When to take P-GUT 40mg ? 

Your physician may prescribe P-GUT on several occasions. The most common one is a pain abdomen due to peptic ulcers. You may have to take for a month or two for this condition. Your doctor may prescribe once or twice daily depending on the severity.

 Besides that, it may be a part of a triple regimen for treating Helicobacter pylori infection as well. It is also a choice in stress ulcers, bleeding ulcers, GERD and Zollinger Ellison syndrome. Doctors also use this drug for prophylaxis of aspiration pneumonia.

How does P-GUT 40mg work in your illness? 

In Peptic Ulcers 

P-GUT 40mg works best for peptic ulcers when you take it once daily. You should take this drug at least one hour before the meal for the best results. The basis by which this great medicine works is by reducing the amount of gastric acid produced in your stomach. After you start this medicine, there is a decrease in the further growth of your ulcer. You may have to use other drugs alongside as well depending upon the severity. 

In Stress ulcers 

Taking P-Gut 40 in stress ulcers reduces the amount of gastric acid. This will improve your conditions. Stress ulcers occur in various traumatic and non-traumatic conditions in your body. So, other medicines, proper rest and stress relief are equally important to allow your body heal.

In Gastroesophageal Reflux disease (GERD)

In GERD, there will be chronic reflux of gastric acid towards your esophagus. By reducing the amount of this acid, there will be a decrease in your symptoms like pain. However, this may take some weeks to manifest. Besides, taking this medicine, you must also make lifestyle changes. This includes taking ample amounts of water, weight loss. Similarly, avoiding food at least 4-5 hours of bed will be synergistic to the drug’s effect. 

In Heartburn

The mechanism by which P-GUT works in this condition is similar to above conditions. By reducing the amount of hydrochloric acid, there is decrease in the mucosal irritation. This relieves pain and soothes your upper gastrointerstinal tract.

How to use P-GUT tablets? 

You must take this drug in an empty stomach at least one hour before the meal. Do not chew, crush or break this enteric coated tablet. If in case, you have to take twice, you must take it one hour before major meal in the evening. Don’t take any solid or liquid items during this one hour interval.

How much time will it take P-GUT to show action? 

As per literature, it will take a minimum of one hour.  At two hours, maximum effect will be seen. The effect  is still half maximal at 24 hours and will last for three days. 

Side effects of P-GUT 40mg

Nausea, abdominal pain and dizziness may be present in 3-5%. Rarely rashes may appear as an adverse effect. Use of more than one year may lead to atrophic gastritis and hypergastrinemia. Long term use may also lead to osteoporosis and decrease in magnesium levels. Rare reports of gynaecomastia and erectile dysfunction can also be found in literature. Consult your doctor to clear any confusion.

Safety Concerns 

Do not take this drug with alcohol. P-GUT 40mg is safe in pregnancy. Considering lactation, contact your doctor before use. You can use this drug while driving. This drug is safe in kidney and liver diseases

What to do if you forget to take P-GUT? 

Take it as soon as possible if you forget at any instance. If you forget one day or two, take it the next time and continue taking it. We do not recommend to double or triple the dose in this context.

Superiority over other brands

P-Gut 40mg is equally efficacious as other brands of pantoprazole. No any specific studies suggest the superiority of this brand over another. But, if your doctor or pharmacist prescribes this drug, take it confidently. There will be no side-effects to worry for.

Superiority over other groups of PPI  

P-GUT 40mg is superior to omeprazole like Pantop 40mg and Panorma 40mg. Though the mechanism of action is similar, pantoprazole has less affinity for cytochrome P450 (CYP2C19). Hence drug interactions are less. Further it is more acid stable and has more oral bioavailability than omeprazole.

Quick tips 
  • Take this medicine in the morning. Avoid any food (solid or liquid), for at least one hour after intake. 
  • You can well tolerate this medicine. But, you must take in time and avoid certain things. 
  • Avoid beverages, alcohol and smoking while taking P-Gut 40mg for best results.  
  • Consult your doctor if you don’t see any effect for 2 weeks. 
  • Don’t stop taking this medicine before consulting your doctor. 
  • Call your doctor immediately if you develop edema, decreased urination, severe vomiting and rashes
P-GUT 40mg

FAQs about P-GUT 40mg

What is the use of P-Gut 40? 

It is a brand name of a pantoprazole, which belongs to the class of proton pump inhibitors. It works by decreasing the production of gastric acid. It’s use are chiefly in peptic ulcer, GERD and heartburn. 

What is the best time to take P-GUT? 

The best time is in the early morning, as soon as you get off the bed. If you have to take twice, take this drug at least one hour before your meal both in the morning and evening. Don’t take any fluids or solid meals during this period. 

How long does it take for work? 

Action starts within one hour. But to get ample relief you will have to take this drug for at least 2-4 weeks. You may still have some symptoms during this time. 

Is P-GUT safe? 

Yes, it is safe in most of the conditions. We recommend talking to your doctor to get best results in this scenario. 

Can I take this drug if I am fasting? 

Yes, you can take Pantop 40mg, if you are fasting or even intermittent fasting. 

Can I stop taking P-GUT if I feel better? 

We don’t recommend this. If you stop taking this medicine abruptly, there may be a surge of acid production. This will worsen your condition. Consult your physician before stopping this drug

What if I overdose this drug? 

Contact your health personnel immediately in this regard. Though there are no such systemic toxicity and antidotes for this drug, we request you be vigilant. 

Does this drug cause weight gain? 

There are only a few reports that may cause weight gain while intaking this drug. So, consult your doctor for any weight gain concerns 

Can I take P-GUT 40mg with alcohol? 

Alcohol doesn’t interfere in the mechanism of action of this drug. But it may increase acid production as a side effect. To prevent further worsening of your stomach, don’t take alcohol with this drug. 

Can I take painkillers with P-GUT? 

P-GUT and other brands are frequently prescribed together with painkillers. NSAIDS are known to cause stress ulcers. Hence, we recommend taking this drug along with painkillers. The dose and duration remains the same as above. 

What other dietary changes should I make while taking this drug? 

We recommend you take a lot of fibers, decrease excess oil and fat consumption. Refrain from caffeine and carbonated beverages.

Can I take antacids with this drug? 

You can take antacids with this drug. But please take them at least two hours prior or after. 

What are the potential side effects of P-GUT 40mg?

The potential side effects are nausea and vomiting. Additionally, there may be rashes, insomnia and abdominal pain. If you consume for more than one year, you may suffer from hypomagnesemia, peripheral neuritis and osteoporosis.

How to use P-GUT 40mg injection?

P-GUT comes with a vial and 10 ml distilled water. By adding this water, you will have to first make the solution. This solution, in a syringe must be given slowly over two to five minutes. You can also store this syringe for 4 hours.

How to use P-GUT 40mg infusion?

The solution that you make in the above step should be mixed with 100 ml of 0.9% normal saline or Ringer’s lactate. This mixture is then given slowly in 10-15 minutes. You can also store this solution. But, be sure to use it within 24 hours.

Summarizing P-GUT 40mg

  • Chemical Class: Sulfinylbenzimidazole
  • Manufacturer: Madras Pharmaceuticals
  • Available in combination: No
  • Addiction: None   
  • Bioavailability: 70-80%
  • Metabolism: Liver 
  • Excretion: Faeces, Urine 
  • Therapeutic class: Gastrointestinal 
  • Action class: PPI 
  • Price: Eight Rupees for tablet and 140 rupees for injection
  • License Number: 
  • Drug Type: Category C 
  • Availability: In all pharmacies, Online
  • Prescription Required? : No for tablet, yes for injection.

Alternatives to P-GUT 40mg

  1. Pantop 40mg by Asian Pharmaceuticals
  2. Panorma 40mg by DJPL

Though medical professionals have written content on this website, you must take these for informational purposes only. We request to consult your physician before using any drug and supplements mentioned in this portal.

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