Versican is found in?
b. Inner Layer of annulus fibrosus
c. Outer layer of annulus fibrosus
d. End plate cartilages
e. Vertebral body
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The correct answer is ‘b’
Versican is a proteoglycan found in the inner layer of annulus fibrosus. It is also known as chondroitin sulfate proteoglycan core protein 2 or chondroitin sulfate proteoglycan 2 (CSPG2).
The annulus fibrosus or the outer layer of intervertebral disc has two layers. The outer layer is rich in type I collagen fibres, decorin and biglycan. The inner layer consists of spherical cells, resembling chondrocytes and are rich in collagen I, II and versican