Zes 20mg Omeprazole Capsules: Complete Guide

Zes 20mg omeprazole

Zes 20mg omeprazole capsule is a product of Asian Pharmaceuticals. It is a proton pump inhibitor. Its cost is 6 rupees to the patient.


This brand of omeprazole acts by inhibiting the final common step in gastric acid secretion. It specifically blocks H+/K+ ATPase. This happens in the parietal cells of your stomach. By virtue of this, there is complete abolition of HCL secretion. However, ZES doesn’t have any other actions like anticholinergic or antihistaminic. 

The name, ZES, is fascinating. This company has given its omeprazole capsule in the name of Zollinger Ellison Syndrome (ZES).


  1. Peptic ulcers 
  2. Heartburn 
  3. Stress ulcers 
  4. Gastroesophageal reflux disorders (GERD)
  5. Zollinger Ellison Syndrome (ZES)
  6. Aspiration Pneumonia 

Your doctor may prescribe once or twice daily depending on the severity.

Zes 20mg omeprazole by Asian Pharmaceuticals

Doses in these conditions

For peptic ulcer, the usual dose of Zes is one capsule daily for a minimum of four weeks. However, the duration can prolong up to 8 weeks. However, this depends upon the severity of your ulcer. Similarly, in stress ulcers, the duration is a minimum of two to four weeks. In cases of heartburn your physician may prescribe for 2 weeks. This may prolong depending upon your symptom after 14 days. For GERD, the dose is similar to that of peptic ulcers. The dose for ZES (syndrome) may prolong up to six months. For aspiration pneumonia, the dose is usually 10-14 days.

How to use ZES 20mg omeprazole capsules ?

You must take this drug in an empty stomach at least one hour before the meal. Do not chew, crush or break this enteric coated tablet. 

If you have to take twice, you must take it one hour before a major meal in the evening. Don’t take any solid or liquid items during this one hour interval.

So why should you take ZES one hour before meal? 

It is because food decreases bioavailability of all PPIs. PPIs are proton pump inhibitors and include omeprazole, pantoprazole, rabeprazole and a lot others.

It takes at least one hour for the drug to act over the active H+K+ATPase.  

Side effects of ZES 20mg omeprazoles

Nausea, abdominal pain and dizziness may be present in 3-5%. Rarely rashes may appear as an adverse effect. Use of more than one year may lead to atrophic gastritis and hypergastrinemia. Long term use may also lead to osteoporosis and decrease in magnesium levels. Rare reports of gynaecomastia, peripheral neuritis and erectile dysfunction are also present in literatures. Consult your doctor to clear any confusion.

How does ZES 20mg work in your illness? 

In Peptic Ulcers 

Zes omeprazole capsule works best for peptic ulcers when you take it once daily. You should take this drug at least one hour before the meal for the best results. The basis by which this great medicine works is by reducing the amount of gastric acid produced in your stomach. After you start this medicine, there is a decrease in the further growth of your ulcer. You may have to use other drugs alongside as well depending upon the severity. 

In Heartburn

The mechanism by which Zes 20mg omeprazole works in this condition is similar to above conditions. By reducing the amount of hydrochloric acid, there is a decrease in the mucosal irritation. This relieves pain and soothes your upper gastrointestinal tract.

In Stress ulcers 

Taking this brand of omeprazole in stress ulcers reduces the amount of gastric acid. This will improve your conditions. Stress ulcers occur in various traumatic and non-traumatic conditions in your body. So, other medicines, proper rest and stress relief are equally important to allow your body heal.

In Gastroesophageal Reflux disease (GERD)

In GERD, there will be chronic reflux of gastric acid towards your esophagus. By reducing the amount of this acid, there will be a decrease in your symptoms like pain. However, this may take some weeks to manifest. Besides, taking this medicine, you must also make lifestyle changes. This includes taking ample amounts of water and losing weight

Similarly, avoiding food at least 4-5 hours of bed will be synergistic to the drug’s effect. 

Safety Concerns of Zes 20mg

Do not take this drug with alcohol. Thus drug is safe in pregnancy. Considering lactation, contact your doctor before use. You can use this drug while driving. This drug is safe in kidney and liver diseases. Dose modifications are not usually preferable in kidney and liver ailments.

What to do if you forget to take Zes 20mg.? 

Take it as soon as possible if you forget at any instance. If you forget one day or two, take it the next time and continue taking it. We do not recommend doubling or tripling the dose in this context.

Superiority over other groups of PPI  

The mechanism by which all PPIs work is similar. However, safety of other groups of PPI is more than omeprazole. 

Superiority over other brands of omeprazole 

There is no such difference in potency,  outcome and adverse effects of one or other brands of omeprazole. There is no any comparative studies in Nepalese literature about this issue.

FAQs about Zes

What is the use of Zes 20mg ? 

It is a brand name of a omeprazole, which belongs to the class of proton pump inhibitors. It works by decreasing the production of gastric acid. It’s use is chiefly in peptic ulcer, GERD and heartburn. 

What is the best time to take Zes 20mg omeprazole ? 

The best time is in the early morning, as soon as you get off the bed. If you have to take twice, take this drug at least one hour before your meal both in the morning and evening. Don’t take any fluids or solid meals during this period. 

How long does it take for work? 

Action starts within one hour. But to get ample relief you will have to take this drug for at least 2-4 weeks. You may still have some symptoms during this time. 

Is this omeprazole safe? 

Yes, it is safe in most of the conditions. We recommend talking to your doctor to get best results in this scenario. 

Can I take this drug if I am fasting? 

Yes, you can take ZES capsules, if you are fasting or even intermittent fasting. 

Can I stop taking ZES 20mg if I feel better? 

We don’t recommend this. If you stop taking this medicine abruptly, there may be a surge of acid production. This will worsen your condition. Consult your physician before stopping this drug

What if I overdose with ZES ? 

Contact your health personnel immediately in this regard. Though there are no such systemic toxicity and antidotes for this drug, we request you be vigilant. 

Does this drug cause weight gain? 

There are only a few reports that may cause weight gain while intaking this drug. So, consult your doctor for any weight gain concerns 

Can I take ZES 20mg with alcohol? 

Alcohol doesn’t interfere in the mechanism of action of this drug. But it may increase acid production as a side effect. To prevent further worsening of your stomach, don’t take alcohol with this drug. 

Can I take painkillers with ZES? 

ZES and other brands are frequently prescribed together with painkillers. NSAIDS are known to cause stress ulcers. Hence, we recommend taking this drug along with painkillers. The dose and duration remains the same as above. 

What other dietary changes should I make while taking this drug? 

We recommend you take a lot of fibers, decrease excess oil and fat consumption. Refrain from caffeine and carbonated beverages.

Can I take antacids with this drug? 

You can take antacids with this drug. But please take them at least two hours prior or after. 

What are the potential side effects of ZES?

The potential side effects are nausea and vomiting. Additionally, there may be rashes, insomnia and abdominal pain. If you consume for more than one year, you may suffer from hypomagnesemia, peripheral neuritis and osteoporosis.

Is ZES 20mg omeprazole injection  available?

ZES 20mg as an injection is not available at the moment. However, the company may have plans to launch the injection in near future.

Can I use this drug in COVID-19 infection?

Since, COVID is in rise in Nepal at the moment of this writing, you can take this. In COVID, there are high chances that you may have stress ulcers. ZES 20mg omeprazole can help you in this regards.

Quick tips for ZES 20mg

  • Take this medicine in the morning. Avoid any food (solid or liquid), for at least one hour after intake. 
  • You can well tolerate this medicine. But, you must take in time and avoid certain things. 
  • Avoid beverages, alcohol and smoking while taking ZES for best results.  
  • Consult your doctor if you don’t see any effect for 2 weeks. 
  • Don’t stop taking this medicine before consulting your doctor. 
  • Call your doctor immediately if you develop edema, decreased urination, severe vomiting and rashes

Summary: ZES capsules

  • Chemical Class: Benzimidazole
  • Manufacturer: Asian Pharmaceuticals
  • Available in combination: –
  • Addiction: None   
  • Bioavailability: 70-80%
  • Metabolism: Liver 
  • Excretion: Faeces, Urine 
  • Therapeutic class: PPI
  • Price: Six Rupees for tablet 
  • License Number: 
  • Drug Type: Category C 
  • Availability: In all pharmacies, Online pharmacies in Nepal
  • Prescription Required? : No
Disclaimer about ZES 20mg omeprazole

Though medical professionals have written content on this website, you must take these for informational purposes only. We request to consult your physician before using any drug and supplements mentioned in this portal.

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